血栓素B2、前列腺素及其代谢产物对多形核白细胞的趋化活性。
Chemotactic activity of thromboxane B2, prostaglandins and their metabolites for polymorphonuclear leucocytes.
作者信息
Kitchen E A, Boot J R, Dawson W
出版信息
Prostaglandins. 1978 Aug;16(2):239-44. doi: 10.1016/0090-6980(78)90025-4.
(1) The chemotactic activities of thromboxane B2 (TxB2), PGE2, PGF2alpha, the 15-oxo, 15-oxo-13,14-dihydro and 13,14-dihydro metabolites of PGE2, PGF2alpha, and a metabolite of TxB2 for polymorphonuclear leucocytes (PMN) have been investigated. (2) Thromboxane B2 increased the directional migration of rat peritoneal PMN at a concentration of 2.0 micrograms/ml and of human peripheral neutrophils at a concentration of 0.5 microgram/ml. (3) Neither PGE2, PGF2alpha nor their metabolites showed chemotactic activity for rat peritoneal PMN. (4) PGF2alpha and 15-oxo-13,14-dihydro-thromboxane B2 showed no chemotactic activity for human peripheral PMN. (5) The possible role of thromboxane B2 in inflammation is discussed.
（1）已对血栓素B2（TxB2）、前列腺素E2（PGE2）、前列腺素F2α（PGF2α）、PGE2的15-氧代、15-氧代-13,14-二氢和13,14-二氢代谢物、PGF2α以及TxB2的一种代谢物对多形核白细胞（PMN）的趋化活性进行了研究。（2）血栓素B2在浓度为2.0微克/毫升时可增加大鼠腹腔PMN的定向迁移，在浓度为0.5微克/毫升时可增加人外周中性粒细胞的定向迁移。（3）PGE2、PGF2α及其代谢物对大鼠腹腔PMN均未显示趋化活性。（4）PGF2α和15-氧代-13,14-二氢血栓素B2对人外周PMN未显示趋化活性。（5）讨论了血栓素B2在炎症中的可能作用。
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