Ziegler M G, Milano A J, Lake C R
Clin Exp Hypertens A. 1982;4(4-5):663-74. doi: 10.3109/10641968209061605.
Studies in man and animals suggest increased central noradrenergic activity in hypertension. We can now measure norepinephrine (NE) in cerebrospinal fluid (CSF) accurately and this should provide an index of central noradrenergic activity. NE in CSF is very labile and altered by anxiety, stress, drugs, sodium balance and other factors. When these factors are controlled, NE in CSF appears elevated in essential hypertensives, particularly among young patients. Neurologic diseases that alter NE in CSF cause parallel alterations in blood pressure. Increased central noradrenergic activity is reflected in CSF NE levels and may cause some forms of hypertension.
对人和动物的研究表明，高血压患者中枢去甲肾上腺素能活性增强。我们现在能够准确测量脑脊液（CSF）中的去甲肾上腺素（NE），这应该能提供中枢去甲肾上腺素能活性的一个指标。脑脊液中的去甲肾上腺素非常不稳定，会受到焦虑、压力、药物、钠平衡及其他因素的影响而发生变化。当这些因素得到控制时，原发性高血压患者，尤其是年轻患者脑脊液中的去甲肾上腺素似乎会升高。能改变脑脊液中去甲肾上腺素的神经系统疾病会导致血压出现相应变化。脑脊液中去甲肾上腺素水平反映出中枢去甲肾上腺素能活性增强，可能会引发某些类型的高血压。
