Lake C R, Gullner H G, Polinsky R J, Ebert M H, Ziegler M G, Bartter F C
Science. 1981 Feb 27;211(4485):955-7. doi: 10.1126/science.7466370.
The concentration of norepinephrine in cerebrospinal fluid from patients with essential hypertension is higher than that from healthy normal volunteers, but the concentrations of norepinephrine in plasma from these groups are similar. This finding indicates that central nervous system noradrenergic hyperactivity occurs in essential hypertension but apparently is not reflected in abnormal function of the peripheral sympathetic nervous system in these patients.
原发性高血压患者脑脊液中去甲肾上腺素的浓度高于健康正常志愿者，但这些组血浆中去甲肾上腺素的浓度相似。这一发现表明，原发性高血压患者存在中枢神经系统去甲肾上腺素能亢进，但显然这些患者外周交感神经系统功能异常并未体现出来。
