Kojima I, Ogata E
Endocrinol Jpn. 1982 Feb;29(1):21-5. doi: 10.1507/endocrj1954.29.21.
In an attempt to elucidate the dopaminergic involvement in the regulation of the effect of angiotensin II on the adrenals, plasma aldosterone response to angiotensin II infusion (5 ng/kg/min, for 60 minutes) was studied in five normal volunteers in various experimental conditions. Prior infusion of dopamine (3 micrograms/kg/min) or saline (1000 ml/hour) caused an attenuation of the aldosterone response to angiotensin II. Concurrent infusion of a dopaminergic antagonist, metoclopramide (10 micrograms/kg/min), abolished the inhibitory effect of dopamine and saline. These results suggest that the dopaminergic mechanism is involved in the adaptive aldosterone response of the adrenal to acute saline loading in man.
为了阐明多巴胺能系统在调节血管紧张素II对肾上腺作用中的参与情况，在不同实验条件下，对五名正常志愿者进行了研究，观察其血浆醛固酮对血管紧张素II输注（5纳克/千克/分钟，持续60分钟）的反应。预先输注多巴胺（3微克/千克/分钟）或生理盐水（1000毫升/小时）会导致醛固酮对血管紧张素II的反应减弱。同时输注多巴胺能拮抗剂甲氧氯普胺（10微克/千克/分钟）可消除多巴胺和生理盐水的抑制作用。这些结果表明，多巴胺能机制参与了人体肾上腺对急性生理盐水负荷的适应性醛固酮反应。
