关于米索硝唑在局部晚期头颈癌随机试验中的报告。
A report on misonidazole in randomized trial in locally advanced head and neck cancer.
作者信息
Sealy R, Williams A, Cridland S, Stratford M, Minchinton A, Hallet C
出版信息
Int J Radiat Oncol Biol Phys. 1982 Mar-Apr;8(3-4):339-42. doi: 10.1016/0360-3016(82)90635-6.
PMID:7050035
Abstract
A prospective randomized trial is reported involving 97 patients with locally advanced cancer of the head and neck. Using six large fractions of radiation (3600 rad in 17 days) the addition of misonidazole (2.0gm per m2 body surface) with each fraction did not increase the local control rate at one year. It is thought that this is probably because of an inadequate tumor concentration of the drug.
摘要
报告了一项前瞻性随机试验，涉及97例局部晚期头颈癌患者。采用大分割放疗（17天内给予3600拉德），每次分割时添加甲硝唑（每平方米体表面积2.0克），一年时局部控制率并未提高。据认为，这可能是因为药物在肿瘤中的浓度不足。
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