Paterson I C, Dawes P J, Henk J M, Moore J L
Clin Radiol. 1981 Mar;32(2):225-9. doi: 10.1016/s0009-9260(81)80166-3.
Twenty-nine patients with advanced carcinoma of the upper air and food passages were treated by radiotherapy using a 10-fraction three-week scheme, giving 1.2 g/m2 of misonidazole 4 h before each treatment. Complete tumour regression was observed in 24 of the patients, and at a nine-month follow-up the local tumour control rate is 60%. Sixteen patients developed evidence of peripheral neuropathy. A prospective random controlled trial is recommended to confirm the apparently improved local tumour control from the use of misonidazole in this study.
29例上呼吸道和消化道晚期癌患者采用10次分割、为期3周的放疗方案进行治疗，每次治疗前4小时给予1.2g/m²的米索硝唑。24例患者出现肿瘤完全消退，在9个月的随访中，局部肿瘤控制率为60%。16例患者出现周围神经病变的证据。建议进行一项前瞻性随机对照试验，以证实本研究中使用米索硝唑后局部肿瘤控制情况明显改善。
