Bauer L A, Raisys V A, Watts M T, Ballinger J
J Clin Pharmacol. 1982 May-Jun;22(5-6):276-80. doi: 10.1002/j.1552-4604.1982.tb02674.x.
The pharmacokinetics of thiabendazole and its metabolites were determined after the first dose and during hemodialysis and hemoperfusion in an anephric female patient treated for a strongyloides infection. The half-live, volume of distribution, and clearance for thiabendazole were 1.17 hour, 2.76 liters/kg, and 27.2 ml/min . kg, respectively. While thiabendazole and the 5-OH metabolite did not accumulate during multiple dosing, the glucuronide and sulfate esters accumulated extensively despite hemodialysis and hemoperfusion. Hemodialysis clearances for all compounds were poor. Hemoperfusion removal was much better but declined rapidly after the first hour. If rapid removal of thiabendazole and its metabolites is required, the hemoperfusion column should be changed hourly.
在一名因类圆线虫感染接受治疗的无肾女性患者中，首次给药后以及血液透析和血液灌流期间测定了噻苯达唑及其代谢物的药代动力学。噻苯达唑的半衰期、分布容积和清除率分别为1.17小时、2.76升/千克和27.2毫升/分钟·千克。虽然多次给药期间噻苯达唑和5-羟基代谢物没有蓄积，但尽管进行了血液透析和血液灌流，葡糖醛酸酯和硫酸酯仍大量蓄积。所有化合物的血液透析清除率都很低。血液灌流清除效果要好得多，但在第一小时后迅速下降。如果需要快速清除噻苯达唑及其代谢物，血液灌流柱应每小时更换一次。
