Identification of six substituted 4''-hydroxy-metabolites of of delta1-tetrahydrocannabinol in mouse liver.
作者信息
Harvey D J, Paton W D
出版信息
Res Commun Chem Pathol Pharmacol. 1978 Sep;21(3):435-46.
PMID:705022
Abstract
4''-Hydroxylation is shown to be a major metabolic route for delta1-tetrahydrocannabinol (delta1-THC) in the mouse. Metabolites were extracted from the livers of mice treated with delta1-THC and examined by combined gas chromatography-mass spectrometry. The 7-hydroxy-6alpha,7-dihydroxy-, 6-oxo- and 7-hydroxy-6-oxo- derivatives of 4''-hydroxy-delta1-THC together with the 4''-hydroxy- and 4'',6alpha-dihydroxy-derivatives of delta1-THC-7-oic acid were identified. Only the diol, 4'',7-dihydroxy-delta1-THC has been reported previously.
摘要
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