• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

Identification of six substituted 4''-hydroxy-metabolites of of delta1-tetrahydrocannabinol in mouse liver.

作者信息

Harvey D J, Paton W D

出版信息

Res Commun Chem Pathol Pharmacol. 1978 Sep;21(3):435-46.

PMID:705022
Abstract

4''-Hydroxylation is shown to be a major metabolic route for delta1-tetrahydrocannabinol (delta1-THC) in the mouse. Metabolites were extracted from the livers of mice treated with delta1-THC and examined by combined gas chromatography-mass spectrometry. The 7-hydroxy-6alpha,7-dihydroxy-, 6-oxo- and 7-hydroxy-6-oxo- derivatives of 4''-hydroxy-delta1-THC together with the 4''-hydroxy- and 4'',6alpha-dihydroxy-derivatives of delta1-THC-7-oic acid were identified. Only the diol, 4'',7-dihydroxy-delta1-THC has been reported previously.

摘要

相似文献

1
Identification of six substituted 4''-hydroxy-metabolites of of delta1-tetrahydrocannabinol in mouse liver.
Res Commun Chem Pathol Pharmacol. 1978 Sep;21(3):435-46.
2
Chemical synthesis and biological occurrence of carboxylic acid metabolites of delta1(6)-tetrahydrocannabinol.
Drug Metab Dispos. 1979 May-Jun;7(3):155-61.
3
Identification of in vivo liver metabolites of delta 6-tetrahydrocannabinol produced by the mouse.小鼠产生的δ6-四氢大麻酚的体内肝脏代谢物的鉴定。
Drug Metab Dispos. 1980 May-Jun;8(3):178-86.
4
Identification of glucuronides as in vivo liver conjugates of seven cannabinoids and some of their hydroxy and acid metabolites.鉴定葡糖醛酸苷为七种大麻素及其一些羟基和酸代谢物在体内的肝脏共轭物。
Res Commun Chem Pathol Pharmacol. 1977 Feb;16(2):265-79.
5
Identification of di- and tri-substituted hydroxy and ketone metabolites of delta1-tetrahydrocannabinol in mouse liver.小鼠肝脏中δ1-四氢大麻酚的二取代和三取代羟基及酮代谢物的鉴定
J Pharm Pharmacol. 1977 Aug;29(8):482-6. doi: 10.1111/j.2042-7158.1977.tb11373.x.
6
Studies on the beta-oxidative metabolism of delta 1- and delta 6-tetrahydrocannabinol in the mouse. The in vivo biotransformation of metabolites oxidized in the side chain.小鼠体内δ1-和δ6-四氢大麻酚的β-氧化代谢研究。侧链氧化代谢产物的体内生物转化。
Drug Metab Dispos. 1985 Mar-Apr;13(2):215-9.
7
In vivo metabolism of the ethyl homologues of delta-8-tetrahydrocannabinol and delta-9-tetrahydrocannabinol in the mouse.小鼠体内δ-8-四氢大麻酚和δ-9-四氢大麻酚的乙基同系物的代谢
Biol Mass Spectrom. 1991 May;20(5):324-8. doi: 10.1002/bms.1200200514.
8
In vivo metabolism of the methyl homologues of delta-8-tetrahydrocannabinol, delta-9-tetrahydrocannabinol and abn-delta-8-tetrahydrocannabinol in the mouse.δ-8-四氢大麻酚、δ-9-四氢大麻酚和非那δ-8-四氢大麻酚甲基同系物在小鼠体内的代谢
Biomed Environ Mass Spectrom. 1988 Apr 1;15(7):389-98. doi: 10.1002/bms.1200150706.
9
Identification of the in vivo liver metabolites of (--)-delta 7-tetrahydrocannabinol produced by the mouse.小鼠体内（-）-δ7-四氢大麻酚肝脏代谢产物的鉴定。
Drug Metab Dispos. 1980 Nov-Dec;8(6):439-45.
10
In vivo metabolism of the n-butyl-homologues of delta 9-tetrahydrocannabinol and delta 8-tetrahydrocannabinol by the mouse.小鼠对δ9-四氢大麻酚和δ8-四氢大麻酚正丁基同系物的体内代谢
Xenobiotica. 1988 Apr;18(4):417-27. doi: 10.3109/00498258809041678.