Fuller R W, Snoddy H D
Res Commun Chem Pathol Pharmacol. 1978 Sep;21(3):457-65.
EXP 561, 4-phenyl-bicyclo(2,2,2)octan-1-amine hydrochloride monohydrate, antagonized brain serotonin depletion by p-chloroamphetamine and heart norepinephrine depletion by 6-hydroxydopamine in rats. The antagonism of p-chloroamphetamine action occurred with post- as well as pre-treatment with EXP 561. Simultaneous injection of EXP 561 with p-chloroamphetamine initially antagonized serotonin depletion but the effect diminished by 24 hrs. The antagonism of 6-hydroxydopamine action could be produced only by pre-treatment with EXP 561, post-treatment having no effect. When EXP 561 was injected simultaneously with 6-hydroxydopamine, its antagonistic effect did not decline with time. The duplications of these findings for the interpretation of data on uptake inhibitor antagonism of amine depletors are discussed.
EXP 561，即4-苯基-双环(2,2,2)辛烷-1-胺盐酸盐一水合物，可拮抗大鼠中对氯苯丙胺引起的脑血清素耗竭以及6-羟基多巴胺引起的心脏去甲肾上腺素耗竭。EXP 561在对氯苯丙胺后处理以及预处理时均能产生拮抗作用。将EXP 561与对氯苯丙胺同时注射，最初可拮抗血清素耗竭，但该效应在24小时后减弱。6-羟基多巴胺作用的拮抗仅可通过EXP 561预处理产生，后处理无效。当EXP 561与6-羟基多巴胺同时注射时，其拮抗作用不会随时间下降。本文讨论了这些研究结果的重复情况，以用于解释胺类耗竭剂摄取抑制剂拮抗作用的数据。
