多巴胺在清醒脱水犬血管紧张素II诱导的血管加压素释放中的作用

Role of dopamine in the angiotensin II-induced vasopressin release in the conscious dehydrated dog.

作者信息

Brooks D P, Claybaugh J R

出版信息

J Endocrinol. 1982 Aug;94(2):243-9. doi: 10.1677/joe.0.0940243.

DOI:10.1677/joe.0.0940243

Abstract

The effect of the dopamine antagonist, haloperidol, on arginine-vasopressin (AVP) release induced by angiotensin II was studied in six dehydrated conscious dogs. Angiotensin II (10 ng/kg per min) alone caused a twofold increase (P less than 0.05) in plasma AVP concentration, a 25 mmHg increase (P less than 0.01) in mean arterial blood pressure (ABP) and a 70% decrease (P less than 0.01) in plasma renin activity (PRA). In the presence of haloperidol (3 micrograms/kg per min), angiotensin II caused similar changes in mean ABP (25 mmHg; P less than 0.01) and PRA (-65%, P less than 0.01), but a small insignificant decrease in plasma AVP (-22%). The AVP response to angiotensin II in the presence of haloperidol was significantly (P less than 0.05) different from its response to angiotensin II alone. Neither haloperidol alone nor the two vehicles had any effect on plasma AVP or mean ABP but PRA dropped slightly. The results suggest that a dopaminergic mechanism may be involved in angiotensin II-induced AVP release.

摘要

在六只脱水清醒犬中研究了多巴胺拮抗剂氟哌啶醇对血管紧张素II诱导的精氨酸加压素（AVP）释放的影响。单独使用血管紧张素II（每分钟10纳克/千克）可使血浆AVP浓度增加两倍（P<0.05），平均动脉血压（ABP）升高25毫米汞柱（P<0.01），血浆肾素活性（PRA）降低70%（P<0.01）。在氟哌啶醇（每分钟3微克/千克）存在的情况下，血管紧张素II使平均ABP产生类似变化（25毫米汞柱；P<0.01），PRA降低（-65%，P<0.01），但血浆AVP有轻微的无统计学意义的降低（-22%）。氟哌啶醇存在时血管紧张素II引起的AVP反应与单独使用血管紧张素II时的反应有显著差异（P<0.05）。单独使用氟哌啶醇或两种溶媒对血浆AVP或平均ABP均无影响，但PRA略有下降。结果表明，多巴胺能机制可能参与血管紧张素II诱导的AVP释放。