Gemmell M A, Johnstone P D, Oudemans G
Res Vet Sci. 1978 Jul;25(1):111-2.
Diuredosan has been tested against Echinococcus granulosus and Taenia hydatigena infections in dogs. The drug showed significant activity against T hydatigena, but there was no significant dose response curve against E granulosus in this trial. Two treatments at 50 mg/kg or 100 mg/kg, however, reduced the number of dogs infected with hydatid worms. Worms were still present in some dogs after three treatments at 50 mg/kg. Vomiting and diarrhoea were relatively common sequelae at and above 50 mg/kg.
已在犬类身上对二氯散糠酸酯进行了抗细粒棘球绦虫和泡状带绦虫感染的测试。该药物对泡状带绦虫显示出显著活性,但在本次试验中,针对细粒棘球绦虫未呈现出显著的剂量反应曲线。然而,50毫克/千克或100毫克/千克的两种治疗剂量减少了感染包虫病蠕虫的犬只数量。在50毫克/千克剂量下进行三次治疗后,一些犬只体内仍有蠕虫存在。50毫克/千克及以上剂量时,呕吐和腹泻是相对常见的后遗症。