甲氧苄啶-磺胺甲恶唑在胸部感染治疗中的应用。

The use of trimethoprim-sulfamethoxazole in the treatment of chest infections.

作者信息

Hughes D T, Russell N J

出版信息

Rev Infect Dis. 1982 Mar-Apr;4(2):528-32. doi: 10.1093/clinids/4.2.528.

DOI:10.1093/clinids/4.2.528

Abstract

The use of combinations of trimethoprim (TMP) and sulfamethoxazole (SMZ) for the treatment of chest infections is described. A number of studies have shown that TMP-SMZ is effective treatment for exacerbations of chronic bronchitis. The long-term use of TMP-SMZ as chemoprophylaxis of chronic bronchitis is also described. Conventional doses of TMP-SMZ (320 mg of TMP and 1600 mg of SMZ) have proved most effective in the prevention of chronic bronchitis; the drug combination is nontoxic and does not lead to the emergence of any resistant organisms. The use of TMP-SMZ for the treatment of pneumonia has been previously described. TMP-SMZ has also been found effective for long-term use in the treatment of cystic fibrosis.

摘要

描述了使用甲氧苄啶（TMP）和磺胺甲恶唑（SMZ）联合治疗胸部感染的情况。多项研究表明，TMP-SMZ是治疗慢性支气管炎急性加重的有效药物。还描述了长期使用TMP-SMZ作为慢性支气管炎化学预防的情况。常规剂量的TMP-SMZ（320毫克TMP和1600毫克SMZ）已被证明在预防慢性支气管炎方面最有效；该药物组合无毒，不会导致任何耐药菌的出现。此前已有关于使用TMP-SMZ治疗肺炎的描述。还发现TMP-SMZ长期用于治疗囊性纤维化有效。