Takahashi H, Iwaki Y, Terasaki P I, Okazaki H, Ishizaki M, Sekino H, Momma M, Takemoto S
Transplant Proc. 1982 Jun;14(2):349-54.
Antibody formation was monitored after buffy-coat transfusions were given at weekly intervals for 9 weeks or a single injection of buffy-coat pooled from ten different donors was given. Among patients with no prior transfusion history, 7 patients given repeated transfusions did not develop warm B or T cytotoxins. Among 25 patients receiving pooled buffy-coat, only 1 patient (who had 3 prior pregnancies) developed warm B and T cytotoxins. In contrast, approximately one fourth of patients who had prior blood transfusions developed warm B and T cytotoxins with either repeated or pooled buffy-coat transfusions. We conclude that buffy-coat from 10 donors given weekly or as a single pooled injection does not produce warm B and T cytotoxins in nontransfused patients, but does function as a secondary stimulus in primed patients.
在每周间隔进行9周的血沉棕黄层输血或给予单次注射来自10个不同供体的混合血沉棕黄层后，监测抗体形成情况。在无既往输血史的患者中，7例接受重复输血的患者未产生温反应性B或T细胞毒素。在25例接受混合血沉棕黄层的患者中，只有1例（有3次既往妊娠史）产生了温反应性B和T细胞毒素。相比之下，既往有输血史的患者中约四分之一在接受重复或混合血沉棕黄层输血时产生了温反应性B和T细胞毒素。我们得出结论，每周给予或单次注射来自10个供体的混合血沉棕黄层，在未输血的患者中不会产生温反应性B和T细胞毒素，但在已致敏的患者中可作为二次刺激发挥作用。
