Ljungman S, Aurell M, Hartford M, Wikstrand J, Berglund G
Acta Med Scand. 1982;211(5):351-60. doi: 10.1111/j.0954-6820.1982.tb01961.x.
The relationship between blood pressure (BP) and the renin-angiotensin-aldosterone system was studied in a stratified random sample (n=120) of 49-year-old men selected from a BP screening and covering a wide range of BPs. Only subjects not on antihypertensive treatment were included. None had malignant or secondary hypertension. Plasma renin activity, plasma concentrations of angiotensin II, aldosterone, sodium, potassium and noradrenaline and the 24-hour urinary excretions of sodium, cortisol and noradrenaline were determined. Of these variables, only p-aldosterone was significantly correlated wtih BP, both in the whole study group (R=0.22, p less than 0.02, n=119) and in the subjects with the highest BP range (R=0.36, p less than 0.02, n=30). Of the clinical groups compared, the hypertensive subjects had significantly higher mean p-aldosterone than the borderline and normotensive subjects. Multiple regression analysis showed that the 24-hour urinary excretion of noradrenaline was the factor most strongly correlated to p-aldosterone, suggesting that the sympathetic nervous system might stimulate aldosterone secretion. Our findings indicate that aldosterone may be of importance for the development and maintenance of essential hypertension.
在从血压筛查中选取的49岁男性分层随机样本（n = 120）中研究了血压（BP）与肾素 - 血管紧张素 - 醛固酮系统之间的关系，这些样本涵盖了广泛的血压范围。仅纳入未接受抗高血压治疗的受试者。无一例患有恶性或继发性高血压。测定了血浆肾素活性、血管紧张素II、醛固酮、钠、钾和去甲肾上腺素的血浆浓度以及钠、皮质醇和去甲肾上腺素的24小时尿排泄量。在这些变量中，仅血浆醛固酮与血压显著相关，在整个研究组（R = 0.22，p < 0.02，n = 119）以及血压范围最高的受试者中（R = 0.36，p < 0.02，n = 30）均如此。在比较的临床组中，高血压受试者的平均血浆醛固酮显著高于临界高血压和血压正常的受试者。多元回归分析表明，去甲肾上腺素的24小时尿排泄量是与血浆醛固酮相关性最强的因素，提示交感神经系统可能刺激醛固酮分泌。我们的研究结果表明，醛固酮可能在原发性高血压的发生和维持中起重要作用。
