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巴贝斯虫寄生虫的体外代谢。与伯氏疟原虫相比,罗得西亚巴贝斯虫的氨基酸产生情况。

Metabolism of Babesia parasites in vitro. amino acid production by Babesia rodhaini compared to Plasmodium berghei.

作者信息

Barry D N

出版信息

Aust J Exp Biol Med Sci. 1982 Apr;60(Pt 2):175-80. doi: 10.1038/icb.1982.18.

DOI:10.1038/icb.1982.18
PMID:7052039
Abstract

The in vitro amino acid production by Babesia rodhaini, Plasmodium berghei and uninfected rat erythrocytes was determined following 4 and 18 h of incubation in Krebs Ringer medium. Both parasites produced excess free amino acid. B. rodhaini produced up to 150 times and P. berghei up to 1,100 times as much free amino acid as parasite-free rat erythrocytes. The composition of excess amino acids produced by both parasites had a statistically significant concordance with the amino acid composition of rat haemoglobin, suggesting that haemoglobin was probably the main source of the amino acids produced by the parasites.

摘要

在Krebs Ringer培养基中孵育4小时和18小时后,测定了罗得西亚巴贝斯虫、伯氏疟原虫以及未感染的大鼠红细胞的体外氨基酸生成情况。两种寄生虫均产生了过量的游离氨基酸。罗得西亚巴贝斯虫产生的游离氨基酸量高达无寄生虫大鼠红细胞的150倍,伯氏疟原虫产生的游离氨基酸量高达1100倍。两种寄生虫产生的过量氨基酸组成与大鼠血红蛋白的氨基酸组成具有统计学上的显著一致性,这表明血红蛋白可能是寄生虫产生氨基酸的主要来源。

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1
Metabolism of Babesia parasites in vitro. amino acid production by Babesia rodhaini compared to Plasmodium berghei.巴贝斯虫寄生虫的体外代谢。与伯氏疟原虫相比,罗得西亚巴贝斯虫的氨基酸产生情况。
Aust J Exp Biol Med Sci. 1982 Apr;60(Pt 2):175-80. doi: 10.1038/icb.1982.18.
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Metabolism of Babesia parasites in vitro. Glucose and energy-metabolism and survival of Babesia rodhaini in a basal medium with and without adenosine.
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Biochemistry of intraerythrocytic parasites. II. Comparative studies in carbohydrate metabolism.红细胞内寄生虫的生物化学。II. 碳水化合物代谢的比较研究。
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Biochemistry of intraerythrocytic parasites. I. Identification of enzymes of parasite origin by starch-gel electrophoresis.红细胞内寄生虫的生物化学。I. 通过淀粉凝胶电泳鉴定寄生虫来源的酶。
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引用本文的文献

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Malar J. 2013 Jan 16;12:19. doi: 10.1186/1475-2875-12-19.
2
A malarial cysteine proteinase is necessary for hemoglobin degradation by Plasmodium falciparum.疟原虫半胱氨酸蛋白酶对于恶性疟原虫降解血红蛋白是必需的。
J Clin Invest. 1988 Nov;82(5):1560-6. doi: 10.1172/JCI113766.