Abdalla H S, Hussein H S, Kreier J P
Tropenmed Parasitol. 1978 Sep;29(3):295-306.
Immune serum delayed the onset of parasitemia in both intact and splenectomized mice, but it neither prevented the development of Babesia rodhaini infection nor protected the mice from death even with further supplementation of immune serum during the infection. The protective antibodies in the serum are more effective in their action on free B. rodhaini parasites than on infected erythrocytes; the parasites (free or inside the red cells) being direct targets for the antibodies. Passive administration of the immune serum seemed to inhibit the active development of the host's own immune response. B. rodhaini, unlike Plasmodium berghei, produces surface changes in the membranes of infected erythrocytes and therefore on incubation of infected erythrocytes and therefore on incubation of infected erythrocytes in immune serum there is either entry and subsequent interaction of antibodies with the parasites within the erythrocytes or there is action of antibody with antigen in the erythrocyte membranes. The effect of immune serum on parasitized erythrocytes is greatest when the parasitized cells incubated in immune serum were administered with additional amounts of immune serum, indicating the ability of the immune serum to extend its action in vivo.
免疫血清在完整小鼠和脾切除小鼠中均延迟了寄生虫血症的发作，但它既不能阻止罗得西亚巴贝斯虫感染的发展，也不能保护小鼠免于死亡，即使在感染期间进一步补充免疫血清也是如此。血清中的保护性抗体对游离的罗得西亚巴贝斯虫寄生虫的作用比对感染红细胞的作用更有效；寄生虫（游离的或在红细胞内的）是抗体的直接靶标。被动给予免疫血清似乎抑制了宿主自身免疫反应的活跃发展。与伯氏疟原虫不同，罗得西亚巴贝斯虫会使感染红细胞的膜发生表面变化，因此在免疫血清中孵育感染红细胞时，要么抗体进入红细胞并随后与其中的寄生虫相互作用，要么抗体与红细胞膜中的抗原发生作用。当在免疫血清中孵育的被寄生细胞再额外给予免疫血清时，免疫血清对被寄生红细胞的作用最大，这表明免疫血清能够在体内扩展其作用。
