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通过海马内注射谷氨酸拮抗剂阻断高频节律性慢活动。

Blockade of high frequency rhythmical slow activity by intrahippocampal injection of a glutamic acid antagonist.

作者信息

Destrade C, Ott T

出版信息

Neurosci Lett. 1980 May 15;18(1):73-8. doi: 10.1016/0304-3940(80)90215-3.

DOI:10.1016/0304-3940(80)90215-3
PMID:7052483
Abstract

Intrahippocampal injections of glutamic acid diethylester (GDEE) were performed in rats in order to study a possible implication of glutamate in the mediation of high frequency (8-12 Hz) rhythmical slow activity (RSA) elicited by 100 Hz electrical stimulation of the dorsomedial hypothalamus. This 8-12 Hz RSA was selectively and reversibly suppressed in hippocampal EEG 6 min and 15 min after 150 micrograms or 400 micrograms of GDEE, whereas no modifications were found in the low frequency RSA (6-8 Hz) evoked in hippocampus during exploratory behavior.

摘要

为了研究谷氨酸在介导由100赫兹电刺激背内侧下丘脑引发的高频（8 - 12赫兹）节律性慢活动（RSA）中的可能作用，对大鼠进行了海马内注射二乙谷氨酸酯（GDEE）。在注射150微克或400微克GDEE后的6分钟和15分钟，海马脑电图中的这种8 - 12赫兹RSA被选择性且可逆地抑制，而在探索行为期间海马中诱发的低频RSA（6 - 8赫兹）未发现改变。

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