Cardenas H, Zapata P
Neurosci Lett. 1980 Jul;18(3):317-22. doi: 10.1016/0304-3940(80)90304-3.
Changes in chemosensory responses to i.v. NaCN during i.v. infusions of dopamine (DA) were studied in pentobarbitone-anesthetized cats. After sectioning both carotid nerves, one of them was prepared for electrophysiological recordings of its chemosensory impulses. Basal chemosensory activity was maintained at a reduced level during DA infusions at a rate of 10 micrograms/kg/min. While sensitivity to NaCN was not modified, reactivity to this agent was reduced for low doses, but enhanced for high doses. It is concluded that chemoreceptor responses to histotoxic hypoxia are rectified by DA. This is discussed in terms of a modulatory role of endogenous DA in the generation of carotid body sensory impulses.
在戊巴比妥麻醉的猫中，研究了静脉输注多巴胺（DA）期间对静脉注射氰化钠（NaCN）的化学感受反应变化。切断双侧颈动脉神经后，将其中一根用于电生理记录其化学感受冲动。在以10微克/千克/分钟的速率输注DA期间，基础化学感受活动维持在降低水平。虽然对NaCN的敏感性未改变，但低剂量时对该药物的反应性降低，而高剂量时增强。结论是，化学感受器对组织毒性缺氧的反应由DA纠正。这在内源性DA在颈动脉体感觉冲动产生中的调节作用方面进行了讨论。
