The secondary cytotoxic response to trinitrophenyl (TNP) modified syngeneic lymphocytes: effectors generated in vitro differ from those generated in vivo.

Following priming in vivo, a secondary cytotoxic response to TNP modified syngeneic lymphocytes can be generated by restimulation either in vivo or in vitro. The secondary effectors generated in vivo show H-2 restricted cytotoxicity, in that only TNP modified syngeneic targets are lysed. However, the secondary effectors generated in vitro lyse both TNP modified syngeneic targets and TNP modified congenic targets which differ only at the major histocompatibility complex.