针对同基因三硝基苯（TNP）脾细胞产生的细胞毒性T淋巴细胞对三硝基苯衍生化的H-2不相容靶细胞的交叉反应性裂解。
Cross-reactive lysis of trinitrophenyl (TNP)-derivatized H-2 incompatible target cells by cytolytic T lymphocytes generated against syngeneic TNP spleen cells.
作者信息
Burakoff S J, Germain R N, Benacerraf B
出版信息
J Exp Med. 1976 Dec 1;144(6):1609-20. doi: 10.1084/jem.144.6.1609.
Abstract
Normal spleen cells, when cultured with irradiated trinitrophenyl (TNP)-derivatized syngeneic spleen cells, develop cytotoxic effectors that lyse most effectiviely a TNP-derivatized target that is H-2 compatible with the effector. However, these effectors also lyse to a lesser extent TNP tumor and TNP spleen targets that are H-2 incompatible. This cross-reactive lysis correlates with the degree of cytolysis seen on the TNP-derivatized syngeneic target; it appears to be medicated by Thy 1.2-bearing cells and is inhibited by antisera to the K and/or D loci of the target cell and not by antisera to non-K or non-D surface antigens. Nonradiolabeled TNP-derivatized lymphoid cells syngeneic to either the stimulator or the target are able to competitively inhibit cross-reactive lysis, while TNP chicken red blood cells are unable to specifically inhibit lysis. These data on cross-reactive lysis of TNP-conjugated targets are most consistent with the altered-self hypothesis.
摘要
正常脾细胞与经照射的三硝基苯（TNP）衍生的同基因脾细胞一起培养时，会产生细胞毒性效应细胞，这些效应细胞能最有效地裂解与效应细胞H-2相容的TNP衍生靶细胞。然而，这些效应细胞也会在较小程度上裂解H-2不相容的TNP肿瘤和TNP脾靶细胞。这种交叉反应性裂解与在TNP衍生的同基因靶细胞上观察到的细胞溶解程度相关；它似乎由表达Thy 1.2的细胞介导，并被针对靶细胞K和/或D位点的抗血清所抑制，而不是被针对非K或非D表面抗原的抗血清所抑制。与刺激细胞或靶细胞同基因的未放射性标记的TNP衍生淋巴细胞能够竞争性抑制交叉反应性裂解，而TNP鸡红细胞则不能特异性抑制裂解。这些关于TNP偶联靶细胞交叉反应性裂解的数据与改变的自身假说最为一致。
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