Mellbye O J, Høyeraal H M, Frøland S S
Scand J Rheumatol. 1978;7(2):90-2. doi: 10.3109/03009747809098842.
In patients with juvenile rheumatoid arthritis (JRA), the delayed hypersensitivity found when skin-testing with a panel of memory antigens appeared to be reduced. Since C-reactive protein (CRP) has recently been shown to inhibit various parameters of cellular immunity in vitro, we tested the concentration of CRP in serum from 44 patients with JRA who had previously been tested for delayed hypersensitivity. The mean concentration of CRP in the patients was 32.2mg/l, while in age-and sex-matched controls it was less than 5 mg/l. By scatter diagrams and statistical analysis no association was found between the concentration of CRP and various expressions of delayed hypersensitivity in vivo.
在青少年类风湿性关节炎（JRA）患者中，用一组记忆抗原进行皮肤试验时发现迟发型超敏反应似乎有所降低。由于最近研究表明C反应蛋白（CRP）在体外可抑制细胞免疫的各种参数，我们检测了44例先前已进行迟发型超敏反应检测的JRA患者血清中CRP的浓度。患者CRP的平均浓度为32.2mg/l，而年龄和性别匹配的对照组中该浓度低于5mg/l。通过散点图和统计分析，未发现CRP浓度与体内迟发型超敏反应的各种表现之间存在关联。
