Ring J, Sovak M
Invest Radiol. 1981 May-Jun;16(3):245-8. doi: 10.1097/00004424-198105000-00017.
Both ionic and nonionic, monomeric and dimeric contrast media were found to release serotonin from intact human platelets in vitro. The monomeric contrast media were compared at the concentration range of 25 mg I/ml. Iothalamate was the strongest and the statistically equal metrizamide iopamidol, and P-297 were the weakest releasers. Monomeric and dimeric contrast media were compared at concentration ranges of 50 and 100 mg I/ml. They ranked, in descending order of serotonin releasing potency: iodipamide, iothalamate, P-127, iopamidol, and a statistically indistinguishable group of the monoacid dimer P-286, the nonionic dimer ZK 74 435, and metrizamide. The capability of contrast media to release serotonin seems to be a composite result of their specific physical and molecular structural properties.
研究发现，离子型和非离子型、单体和二聚体造影剂在体外均可从完整的人体血小板中释放血清素。对浓度范围为25 mg I/ml的单体造影剂进行了比较。异泛影酸盐是最强的血清素释放剂，与甲泛葡胺、碘帕醇在统计学上相当，而P-297是最弱的释放剂。对浓度范围为50和100 mg I/ml的单体和二聚体造影剂进行了比较。它们按血清素释放能力从高到低排序为：碘番酸、异泛影酸盐、P-127、碘帕醇，以及在统计学上无显著差异的一组单酸二聚体P-286、非离子二聚体ZK 74 435和甲泛葡胺。造影剂释放血清素的能力似乎是其特定物理和分子结构特性的综合结果。
