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老年抑郁症患者中羟化去甲丙咪嗪浓度的改变。

Altered hydroxydesipramine concentrations in elderly depressed patients.

作者信息

Kitanaka I, Ross R J, Cutler N R, Zavadil A P, Potter W Z

出版信息

Clin Pharmacol Ther. 1982 Jan;31(1):51-5. doi: 10.1038/clpt.1982.8.

DOI:10.1038/clpt.1982.8
PMID:7053304
Abstract

Recent reports demonstrate that hydroxy metabolites of desipramine (DMI) have pharmacologic activity and do not just produce side effects. In patients treated with DMI, we determined the ratio of 2-hydroxydesipramine (2-OH-DMI) to drug at steady state. The ratios in the elderly patients were higher than in younger patients, and whereas plasma levels of 2-OH-DMI increased with age, urinary clearances decreased. The known decrease in glomerular filtration with age may explain the selective increase of 2-OH-DMI concentration in the elderly.

摘要

最近的报告表明，去甲丙咪嗪（DMI）的羟基代谢物具有药理活性，而不仅仅是产生副作用。在接受DMI治疗的患者中，我们测定了稳态时2-羟基去甲丙咪嗪（2-OH-DMI）与药物的比率。老年患者的该比率高于年轻患者，并且随着年龄增长，2-OH-DMI的血浆水平升高，而尿清除率降低。已知随着年龄增长肾小球滤过会下降，这可能解释了老年人中2-OH-DMI浓度的选择性增加。

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Altered hydroxydesipramine concentrations in elderly depressed patients.老年抑郁症患者中羟化去甲丙咪嗪浓度的改变。
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