血吸虫病中的肝纤维化：虫卵肉芽肿在体外分泌成纤维细胞刺激因子。
Hepatic fibrosis in schistosomiasis: egg granulomas secrete fibroblast stimulating factor in vitro.
作者信息
Wyler D J, Wahl S M, Wahl L M
出版信息
Science. 1978 Oct 27;202(4366):438-40. doi: 10.1126/science.705337.
PMID:705337
Abstract
Cytosol extracts and culture supernatants of isolated egg granulomas obtained from livers of mice with Schistosoma mansoni infection stimulated fibroblasts to incorporate tritiated thymidine and to proliferate in vitro. This finding suggests that hepatic granulomas may play a role in regulating hepatic fibrosis in Schistosoma mansoni infections.
摘要
从感染曼氏血吸虫的小鼠肝脏中分离出的虫卵肉芽肿的胞质提取物和培养上清液，可刺激成纤维细胞掺入氚标记的胸腺嘧啶核苷并在体外增殖。这一发现表明，肝脏肉芽肿可能在曼氏血吸虫感染中调节肝纤维化过程中发挥作用。
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