Emkey R D, Mills J A
JAMA. 1982 Jan 1;247(1):55-7.
To assess the effects of long-term aspirin ingestion on renal function, we studied all of the patients at the Massachusetts General Hospital Arthritis Clinic who had been taking aspirin continuously for ten or more years. Aspirin ingestion was documented by multiple, random, unannounced blood salicylate levels. Most of these 46 patients had seropositive rheumatoid arthritis. All creatinine and BUN levels were normal. Maximum recorded specific gravities were greater than 1.019 in 43 of 46 patients. These data suggest that long-term salicylate ingestion does not cause renal damage.
为评估长期服用阿司匹林对肾功能的影响，我们研究了麻省总医院关节炎诊所所有连续服用阿司匹林十年或更长时间的患者。通过多次随机、不预先通知的血清水杨酸盐水平记录阿司匹林的服用情况。这46名患者中的大多数患有血清阳性类风湿性关节炎。所有肌酐和尿素氮水平均正常。46名患者中有43名的最高记录比重超过1.019。这些数据表明，长期摄入水杨酸盐不会导致肾损伤。
