Lentz T L, Burrage T G, Smith A L, Crick J, Tignor G H
Science. 1982 Jan 8;215(4529):182-4. doi: 10.1126/science.7053569.
Rabies virus was found on mouse diaphragms and on cultured chick myotubes in a distribution coinciding with that of the acetylcholine receptor. Treatment of the myotubes with alpha-bungarotoxin and d-tubocurarine before the addition of the virus reduced the number of myotubes that became infected with rabies virus. These findings together suggest that acetylcholine receptors may serve as receptors for rabies virus. The binding of virus to acetylcholine receptors, which are present in high density at the neuromuscular junction, would provide a mechanism whereby the virus could be locally concentrated at sites in proximity to peripheral nerves facilitating subsequent uptake and transfer to the central nervous system.
在小鼠膈肌和培养的鸡肌管上发现了狂犬病毒，其分布与乙酰胆碱受体的分布一致。在添加病毒之前，用α-银环蛇毒素和d-筒箭毒碱处理肌管，可减少感染狂犬病毒的肌管数量。这些发现共同表明，乙酰胆碱受体可能作为狂犬病毒的受体。病毒与在神经肌肉接头处高密度存在的乙酰胆碱受体结合，将提供一种机制，使病毒能够在周围神经附近的部位局部浓缩，便于随后摄取并转移至中枢神经系统。
