David P, Denis P, Nouvet G, Pasquis P, Lefrançois R, Morère P
Bull Eur Physiopathol Respir. 1982 Jan-Feb;18(1):81-6.
The coexistence of gastroesophageal reflux (GER) and respiratory diseases has led us to raise three questions : 1) how frequent is GER in patients with chronic bronchitis?, 2) is the respiratory function in patients with chronic bronchitis different when they have a GER and when they do not?, 3) is the GER different in patients with chronic bronchitis and in subjects not suffering with chronic bronchitis? The study of esophageal pH after a test meal showed there was a GER in 29 out of the 47 patients studied. The measurements of lung volume, air flow, pulmonary compliance, as well as the alveolo-capillary transfer of carbon monoxide, showed that there was no difference in the lung function of bronchitics whether they had a reflux or not. On the other hand, refluxes are less frequent but longer in patients having bronchitis and a GER, than in those having a GER but not having bronchitis. This must be linked to a low esophageal clearance which could be related to the attack of bronchitis. Only a well carried out prospective study of the treatment of GER in patients will reveal if the reflux increases bronchitic symptoms.
胃食管反流（GER）与呼吸道疾病并存促使我们提出三个问题：1）慢性支气管炎患者中GER的发生率有多高？2）慢性支气管炎患者有GER和无GER时呼吸功能是否不同？3）慢性支气管炎患者与非慢性支气管炎患者的GER情况是否不同？试餐后食管pH值研究表明，在所研究的47例患者中有29例存在GER。肺容量、气流、肺顺应性以及一氧化碳的肺泡-毛细血管转运测量结果显示，无论是否有反流，支气管炎患者的肺功能并无差异。另一方面，患有支气管炎且有GER的患者反流发生频率较低但持续时间较长，比有GER但无支气管炎的患者情况更为严重。这一定与食管清除率降低有关，而食管清除率降低可能与支气管炎发作有关。只有对患者GER治疗进行精心的前瞻性研究，才能揭示反流是否会加重支气管炎症状。
