Burnand K G, Clemenson G, Whimster I, Gaunt J, Browse N L
Br J Surg. 1982 Jan;69(1):41-4. doi: 10.1002/bjs.1800690114.
An increased number of skin capillaries has been found in human skin subjected to sustained venous hypertension. To investigate this observation, venous hypertension was produced in the hind limb of Greyhounds by fashioning an arteriovenous (AV) fistula between the femoral vessels. This caused an increase in the number of capillaries in the skin of the lower leg. The capillary permeability of normal legs and legs subjected to chronic venous hypertension was then studied by observing the movement of radioactive molecules from the plasma to the fluid within Guyton capsules. Fibrinogen, a large molecule, leaked out of the capillaries significantly faster in the limbs with a high venous pressure and an enlarged capillary bed. It is suggested that the increase in the size and permeability of the dermal skin capillaries secondary to prolonged venous hypertension is the cause of lipodermatosclerosis and venous ulceration.
在持续静脉高压状态下的人体皮肤中，已发现皮肤毛细血管数量增加。为研究这一现象，通过在灵缇犬后肢的股血管之间构建动静脉（AV）瘘来制造静脉高压。这导致小腿皮肤中的毛细血管数量增加。随后，通过观察放射性分子从血浆向盖顿胶囊内液体的移动，研究了正常腿部和遭受慢性静脉高压腿部的毛细血管通透性。纤维蛋白原是一种大分子，在静脉压高且毛细血管床扩大的肢体中，其从毛细血管漏出的速度明显更快。有人提出，长期静脉高压继发的真皮皮肤毛细血管大小和通透性增加是脂性皮肤硬化症和静脉溃疡的病因。
