Leach R D, Browse N L
Br J Surg. 1985 Apr;72(4):275-8. doi: 10.1002/bjs.1800720409.
The effect of acute and chronic venous hypertension on the lymph draining from the hind limb has been studied in 10 dogs. Acute venous hypertension was produced by venous occlusion, and chronic venous hypertension by fashioning an arteriovenous fistula in the groin. Acute venous hypertension trebled the lymph flow and doubled its fibrinogen concentration thus increasing the net transport of fibrinogen across the interstitial space by 600 per cent. Chronic venous hypertension had a similar effect and caused the appearance of alpha-2-antiplasmin in the lymph. The fibrinolytic activity of the lymph did not change significantly in either group of experiments. These results suggest that the deposition of interstitial fibrin seen in the skin of the postphlebitic limb is related to an increased concentration of interstitial fluid fibrin, and to the appearance of the fibrinolytic inhibitor, alpha-2-antiplasmin, without a concomitant increase of fibrinolytic activator.
在10只狗身上研究了急慢性静脉高压对后肢淋巴引流的影响。急性静脉高压通过静脉闭塞产生，慢性静脉高压通过在腹股沟处形成动静脉瘘产生。急性静脉高压使淋巴流量增加两倍，纤维蛋白原浓度增加一倍，从而使纤维蛋白原跨间质空间的净转运增加600%。慢性静脉高压有类似作用，并导致淋巴中出现α-2-抗纤溶酶。在两组实验中，淋巴的纤溶活性均无明显变化。这些结果表明，静脉炎后肢体皮肤中所见的间质纤维蛋白沉积与间质液纤维蛋白浓度增加以及纤维蛋白溶解抑制剂α-2-抗纤溶酶的出现有关，而纤维蛋白溶解激活剂没有相应增加。
