Baker S R, Wolfe R A
Cancer. 1982 Jan 1;49(1):163-9. doi: 10.1002/1097-0142(19820101)49:1<163::aid-cncr2820490132>3.0.co;2-8.
Data collected from review of 99 patients with carcinoma of the nasopharynx was submitted for statistical analysis. The purpose of the analysis was to determine patient, tumor and treatment factors that influence survival. The only patient factor observed to influence survival was patient age (P = 0.05). Greatest survival was noted for patients in the age group 0 to 20 years (44%), while poorest survival rates were in patients over 60 years of age (14%). Tumor factors influencing survival included the location of regional metastases (P = 0.05). Homolateral cervical metastases was associated with survival rates approximating 30% compared with 10% when bilateral metastases were present. Survival decreased markedly as cervical metastases progressed from the upper third of the neck to involvement of the middle and lower thirds. Survival was 20% when nodal involvement was confined to the upper neck compared with 8% when metastases extended to lower cervical regions. The only treatment factor apparently influencing survival was duration of therapy (P = 0.08). Longer treatment periods offered better five-year control rates. Higher dosage levels of radiotherapy were associated with improved survival, but not significantly so.
对99例鼻咽癌患者的回顾性研究收集的数据进行了统计分析。分析目的是确定影响生存的患者、肿瘤及治疗因素。观察到的唯一影响生存的患者因素是患者年龄（P = 0.05）。0至20岁年龄组患者的生存率最高（44%），而60岁以上患者的生存率最低（14%）。影响生存的肿瘤因素包括区域转移部位（P = 0.05）。同侧颈部转移患者的生存率约为30%，而双侧转移患者的生存率为10%。随着颈部转移从颈部上三分之一进展至中三分之一和下三分之一，生存率显著下降。当淋巴结受累局限于上颈部时，生存率为20%，而转移扩展至下颈部区域时生存率为8%。唯一明显影响生存的治疗因素是治疗持续时间（P = 0.08）。较长的治疗期提供了更好的五年控制率。较高剂量的放疗与生存率提高相关，但无显著差异。
