Cassileth B R, Clark W H, Heiberger R M, March V, Tenaglia A
Cancer. 1982 Jan 1;49(1):198-200. doi: 10.1002/1097-0142(19820101)49:1<198::aid-cncr2820490138>3.0.co;2-9.
The correlation between time to diagnosis and thickness of lesion in patients with superficial spreading melanoma was explored. Charts of 245 patients diagnosed since 1976 were reviewed for data on lesion duration and time since elevation (as perceived by patients); and the degree of elevation (if any); thickness, and diameter of lesion (as measured histologically). No correlation emerged between time to diagnosis and the biologic state of disease as reflected by thickness. The majority of melanomas in this series were not recognized by patients in an early, pre-elevation, low-risk phase. Whether an emphasis on identification of melanoma in this phase will lead to an increase in the percent of patients presenting with biologically early, curable disease remains to be tested.
对浅表扩散性黑色素瘤患者的诊断时间与病灶厚度之间的相关性进行了探讨。回顾了自1976年以来确诊的245例患者的病历，以获取病灶持续时间和自隆起（患者所感知）以来的时间数据；以及隆起程度（如有）、厚度和病灶直径（组织学测量）。诊断时间与厚度所反映的疾病生物学状态之间未发现相关性。该系列中的大多数黑色素瘤在早期、隆起前、低风险阶段未被患者识别。强调在此阶段识别黑色素瘤是否会导致生物学上早期可治愈疾病的患者比例增加，仍有待检验。
