Amalric R, Santamaria F, Robert F, Seigle J, Altschuler C, Kurtz J M, Spitalier J M, Brandone H, Ayme Y, Pollet J F, Burmeister R, Abed R
Cancer. 1982 Jan 1;49(1):30-4. doi: 10.1002/1097-0142(19820101)49:1<30::aid-cncr2820490107>3.0.co;2-l.
Since 1960 more than 3000 consecutive patients with operable infiltrating breast carcinoma were treated by radiation therapy with or without primary limited surgery, which usually consisted of local excision. For tumors smaller than or equal to 5 cm the ten-year crude survival rate is 77% for patients without palpable axillary nodes (T1-2N0) and 63% for patients having axillary adenopathy (T1-2N0). For operable tumors exceeding 5 cm of diameter (T3N0-1) the ten-year crude survival is 34%. Thirty-five percent of the patients alive free of disease at ten years required a secondary operation for presumed local or regional tumor persistence or recurrence, although no residual disease was found in 24% of the operative specimens. Local-regional recurrence had no adverse effect on ten-year survival. This conservative approach offers most women with operable breast cancer an excellent chance at breast preservation with the same chance for ten-year survival as with radical mastectomy.
自1960年以来，超过3000例连续的可手术浸润性乳腺癌患者接受了放射治疗，部分患者还接受了一期有限手术，通常为局部切除。对于直径小于或等于5cm的肿瘤，无可触及腋窝淋巴结的患者（T1-2N0）十年粗生存率为77%，有腋窝淋巴结肿大的患者（T1-2N0）为63%。对于直径超过5cm的可手术肿瘤（T3N0-1），十年粗生存率为34%。十年时无病存活的患者中有35%因推测局部或区域肿瘤持续存在或复发而需要二次手术，尽管24%的手术标本中未发现残留疾病。局部区域复发对十年生存率没有不利影响。这种保守方法为大多数患有可手术乳腺癌的女性提供了保留乳房的绝佳机会，其十年生存率与根治性乳房切除术相同。
