Morphology of adenocarcinoma in situ of the uterine cervix: a study of 14 cases.

Fourteen cases of adenocarcinoma in situ (ACIS) of the cervix in patients 30 to 52 years old were studied. In its pure form (four cases, ACIS was discovered cytologically, but when associated with a squamous abnormality (ten cases), it was found histologically. Two different types of ACIS were distinguished both histologically and cytologically. The first type, which was similar to the common form reported in the medical literature, predominated in 12 cases, and consisted of cells with hyperchromatic and pseudo-stratified nuclei. The second type, which predominated in two cases, displayed a conspicuous structural disorder with unequal, larger, and often clear nuclei containing enlarged nucleoli.