Irwin R S, Whitaker S, Pratter M R, Millard C E, Tarpey J T, Corwin R W
Chest. 1982 Jan;81(1):31-5. doi: 10.1378/chest.81.1.31.
To determine the duration and persistence of gram-negative bacillary (GNB) oropharyngeal colonization over a specified period and the risk of subsequent GNB pneumonia developing in nursing home patients, we prospectively cultured for 31 weeks the oropharynges of patients in a skilled nursing facility. Over a 31-week period, an average of 13.8 percent of the patients showed colonization (weekly prevalence rates ranged from 0 to 29 percent). No patient had pneumonia during the study period. We concluded that the presence of GNB in the oropharynx of our patients is transient, continually changing over an extended period, and that GNB colonization as a transient occurrence is not directly associated with an increased risk of GNB pneumonia. Our data also emphasize the limitations of previously described single-culture survey studies in predicting the importance of GNB oropharyngeal colonization.
为确定革兰氏阴性杆菌（GNB）口咽部定植在特定时间段内的持续时间和持续性，以及疗养院患者随后发生GNB肺炎的风险，我们对一家专业护理机构的患者口咽部进行了为期31周的前瞻性培养。在31周的时间里，平均有13.8%的患者出现定植（每周患病率从0%到29%不等）。研究期间没有患者发生肺炎。我们得出结论，我们患者口咽部GNB的存在是短暂的，在较长时间内持续变化，并且作为一种短暂现象的GNB定植与GNB肺炎风险增加没有直接关联。我们的数据还强调了先前描述的单培养调查研究在预测GNB口咽部定植重要性方面的局限性。
