Bray G A, Shimomura Y, Ohtake M, Walker P
Endocrinology. 1982 Jan;110(1):47-50. doi: 10.1210/endo-110-1-47.
The salivary glands of genetically obese male mice are significantly smaller than those of lean male mice, but the salivary glands of female mice do not differ in weight. The increases in weight of salivary glands in male mice after treatment with T3 at 50, 150, or 500 ng/day or with several doses of isoproterenol were comparable on a percentage basis, but the weights in the ob/ob mice were always smaller than any of those in the lean mice. Measurements of nerve growth factor (NGF) in several tissues showed a significantly lower concentration in the salivary glands of obese female mice than in same tissue from female lean mice. There were no differences in NGF levels in brown fat or in the cortex, cerebellum, or brain stem. The concentration of epidermal growth factor, in contrast to that of NGF, was not lower in the salivary glands of obese mice. Testosterone increased the weight of the salivary glands, spleen, and kidney in obese female mice, but the weight of the salivary glands in lean animals remained significantly higher than that in the obese mice both with and without treatment. Testosterone significantly increased the NGF concentration in salivary glands, but the values in treated male mice were only one tenth those in the treated lean animals.
基因肥胖雄性小鼠的唾液腺明显小于瘦雄性小鼠的唾液腺，但雌性小鼠的唾液腺重量没有差异。用50、150或500 ng/天的T3或几种剂量的异丙肾上腺素处理后，雄性小鼠唾液腺重量的增加在百分比基础上是相当的，但ob/ob小鼠的重量总是小于瘦小鼠中的任何一组。对几种组织中神经生长因子（NGF）的测量显示，肥胖雌性小鼠唾液腺中的浓度明显低于瘦雌性小鼠相同组织中的浓度。棕色脂肪、皮质、小脑或脑干中的NGF水平没有差异。与NGF相反，肥胖小鼠唾液腺中表皮生长因子的浓度并不低。睾酮增加了肥胖雌性小鼠唾液腺、脾脏和肾脏的重量，但无论是否治疗，瘦动物唾液腺的重量仍明显高于肥胖小鼠。睾酮显著增加了唾液腺中NGF的浓度，但治疗后雄性小鼠的值仅为治疗后瘦动物的十分之一。
