Colby T V, LaBrecque D R
Gastroenterology. 1982 Feb;82(2):339-45.
Four cases of fulminant hepatic disease caused by lymphoreticular infiltration are described. All 4 patients died within a few weeks and clinical diagnoses included viral hepatitis, alcoholic hepatitis, and drug hepatitis. A diagnosis of malignancy was made prior to autopsy in only 1 of the 4 patients. Autopsies revealed typical malignant histiocytosis in 3 patients and the fourth had a primitive lymphoreticular malignancy with malignant histiocytosis the favored diagnosis. The extent of the liver infiltrate as judged histologically was mild compared with the severe clinical illness. Randomly scattered foci of necrosis associated with the malignant infiltrate were seen in the 2 patients who had marked elevations of serum glutamic oxaloacetic transaminase.
本文描述了4例因淋巴网状细胞浸润引起的暴发性肝病。所有4例患者均在数周内死亡，临床诊断包括病毒性肝炎、酒精性肝炎和药物性肝炎。4例患者中仅有1例在尸检前被诊断为恶性肿瘤。尸检显示，3例患者患有典型的恶性组织细胞增多症，第4例患有原始淋巴网状恶性肿瘤，恶性组织细胞增多症为首选诊断。与严重的临床疾病相比，组织学判断的肝脏浸润程度较轻。在血清谷氨酸草酰乙酸转氨酶显著升高的2例患者中，可见与恶性浸润相关的随机散在坏死灶。
