Van Cauter E, Desir D, Refetoff S, Spire J P, Neol P, H'Hermite M, Robyn C, Copinschi G
J Clin Endocrinol Metab. 1982 Jan;54(1):70-5. doi: 10.1210/jcem-54-1-70.
The concept of concomitance between nadirs and peaks of plasma levels of PRL and, respectively, rapid eye movement (REM) and non-REM stages in sleep was reevaluated using 24 nighttime profiles of plasma PRL collected at 15-min intervals and the corresponding polygraphic recordings of sleep. The subjects were 5 healthy young male adults. Data were examined using the methodology described in the original report, consisting of averaging across individual nights PRL levels during REM and non-REM sleep stages as well as using a detailed spike by spike analysis of each individual pair of hormonal and sleep profiles. We showed that in our subjects, there was no relation, other than a purely random one, between episodic PRL fluctuations in plasma and REM-non-REM cycles.
利用每隔15分钟采集一次的24份夜间血浆催乳素（PRL）水平数据以及相应的睡眠多导记录，重新评估了PRL血浆水平的最低点和峰值分别与睡眠中的快速眼动（REM）和非快速眼动阶段之间的伴随关系。研究对象为5名健康的年轻男性成年人。采用原始报告中描述的方法对数据进行检查，包括对REM和非REM睡眠阶段的PRL水平进行各夜间平均，以及对每一对激素和睡眠数据进行逐点详细分析。我们发现，在我们的研究对象中，血浆中PRL的 episodic波动与REM - 非REM周期之间除了纯粹的随机关系外，没有其他关联。
