Swartz C M
J Nerv Ment Dis. 1982 Jan;170(1):50-2. doi: 10.1097/00005053-198201000-00008.
Two patients are described who depended on potentiation of tricyclic antidepressant effectiveness by thyroid superfunction for remission of an episode of unipolar depression. In one case, the excess thyroid hormone was the product of hyperthyroidism; whenever the hyperthyroidism was treated, the remission induced by imipramine was negated. In the other case, triiodothyronine was exogenously administered. These case studies suggested that some patients may require larger doses than 25 microgram of triiodothyronine per day for effective antidepressant potentiation. Some endocrinological similarities between hyperthyroidism and depressive illness are discussed.
本文描述了两名单相抑郁发作患者，他们依靠甲状腺功能亢进增强三环类抗抑郁药的疗效来缓解症状。在一个病例中，甲状腺激素过量是甲状腺功能亢进的结果；每当治疗甲状腺功能亢进时，丙咪嗪诱导的缓解就会被消除。在另一个病例中，外源性给予三碘甲状腺原氨酸。这些病例研究表明，一些患者可能需要每天超过25微克的三碘甲状腺原氨酸才能有效增强抗抑郁作用。文中讨论了甲状腺功能亢进与抑郁症之间的一些内分泌学相似之处。
