Joffe R T, Singer W
Department of Psychiatry, St. Michael's Hospital, Toronto, Ont., Canada.
Psychiatry Res. 1990 Jun;32(3):241-51. doi: 10.1016/0165-1781(90)90029-5.
Several studies suggest that small amounts of triiodothyronine (T3) will convert tricyclic antidepressant nonresponders into responders within a few days to a few weeks. As thyroxine (T4) is converted to T3 to have its physiological effect, it has been assumed that T4 would have a similar antidepressant effect to that of T3. We carried out a randomized, double-blind evaluation of the antidepressant-potentiating effect of T3 as compared with T4. Significantly more patients responded to 3 weeks of T3 as compared with T4 potentiation. Small but significant differential effects of the two thyroid hormones were noted on the Hamilton Rating Scale for Depression.
多项研究表明，少量的三碘甲状腺原氨酸（T3）能在几天到几周内将三环类抗抑郁药无反应者转变为有反应者。由于甲状腺素（T4）会转化为T3以发挥其生理作用，因此人们认为T4会具有与T3类似的抗抑郁作用。我们对T3与T4的抗抑郁增效作用进行了一项随机双盲评估。与T4增效相比，显著更多的患者对3周的T3有反应。在汉密尔顿抑郁量表上，注意到这两种甲状腺激素有微小但显著的差异效应。
