Burns A H, Montini J
Life Sci. 1982 Jan 4;30(1):29-37. doi: 10.1016/0024-3205(82)90632-4.
Oxygen consumption was measured on suspensions of calcium tolerant myocytes obtained from hearts of Spontaneously Hypertensive Rats (SHR) and normotensive Wistar Kyoto Rats (WKY). Oxygen consumptions of the isolated cells were not significantly different from each other either in the presence or absence of added calcium (1.5 mM). Additionally, there was excellent agreement between the oxygen consumption of the isolated cells and estimates of basal oxygen consumption between work and myocardial oxygen utilization in isolated perfused working hearts. At any given workload there was no significant difference in oxygen consumption between SHR hearts and WKY hearts. The mechanical performance of the SHR hearts was lower compared to that of the WKY hearts at low preloads. At high preloads and high afterloads the SHR hearts developed higher pressures than did hearts obtained from WKY rats. The data suggest that: (1) basal oxygen consumption of the two hearts are similar and (b) the contractile defects in the SHR heart are not the result of hypoxia.
对从自发性高血压大鼠（SHR）和血压正常的Wistar Kyoto大鼠（WKY）心脏获取的耐钙心肌细胞悬液进行了氧消耗测量。在添加钙（1.5 mM）或不添加钙的情况下，分离细胞的氧消耗彼此之间没有显著差异。此外，分离细胞的氧消耗与离体灌注工作心脏中工作与心肌氧利用之间的基础氧消耗估计值之间具有极好的一致性。在任何给定的工作负荷下，SHR心脏和WKY心脏的氧消耗没有显著差异。在低预负荷下，SHR心脏的机械性能低于WKY心脏。在高预负荷和高后负荷下，SHR心脏产生的压力高于从WKY大鼠获得的心脏。数据表明：（1）两颗心脏的基础氧消耗相似；（2）SHR心脏的收缩缺陷不是缺氧的结果。
