Souroujon M, Ashkenazi A, Lupo M, Levin S, Hegesh E
Am J Clin Pathol. 1982 Jan;77(1):82-6. doi: 10.1093/ajcp/77.1.82.
Of the various common assayed parameters of iron metabolism, serum ferritin levels are the most discriminatory in distinguishing between non-treated celiac disease and other gastrointestinal disorders in the pediatric age group. Patients on normal diets usually have very low ferritin levels that increase at an average rate of 1 microgram/1/month when placed on a gluten-free diet. When the patient returns to a normal diet, however, ferritin levels decrease rapidly at an average rate of about 4 microgram/1/month. There is a relationship between abnormal intestinal changes and low ferritin levels in celiac disease with improvement in both when the patient is on a gluten-free diet. It is suggested that serial blood ferritin evaluations together with the leukocyte migration inhibition factor production assay should eliminate the need for invasive intestinal biopsies for the confirmation and possible follow-up to response to treatment.
在铁代谢的各种常见检测参数中，血清铁蛋白水平在区分小儿年龄组未经治疗的乳糜泻和其他胃肠道疾病方面最具鉴别力。正常饮食的患者通常铁蛋白水平很低，开始无麸质饮食后，铁蛋白水平平均每月以1微克/升的速度上升。然而，当患者恢复正常饮食时，铁蛋白水平会以约4微克/升的平均速度迅速下降。乳糜泻中肠道异常变化与低铁蛋白水平之间存在关联，患者采用无麸质饮食时两者均会改善。有人建议，连续进行血液铁蛋白评估并结合白细胞迁移抑制因子产生试验，应可无需进行侵入性肠道活检来确诊并可能跟进治疗反应。
