Dinari G, Zahavi I, Marcus H, Moroz C
Division of Paediatric Gastroenterology, Beilinson Medical Center, Sackler School of Medicine, Tel Aviv University, Petah Tiqva, Israel.
Gut. 1991 Sep;32(9):999-1003. doi: 10.1136/gut.32.9.999.
Placental ferritin is a tumour associated antigen present in the serum of patients with active Hodgkin's and non-Hodgkin's lymphoma, and the serum values fall during remission of the disease. There is no correlation between placental and total blood ferritin values. Because of the strong association between coeliac disease and lymphoma, 19 children with active and 25 with inactive coeliac disease were screened for the presence of placental ferritin. Thirty two children with other intestinal disorders served as controls. Placental ferritin was identified by using a monoclonal antibody in an ELISA procedure. The mean (SEM) placental ferritin value in the control serum was 12.6 (2.4) while the values in serum of patients with active and inactive coeliac disease were 117 (22.8) and 43.8 (10.2) U/ml respectively. Patients with active coeliac disease differed significantly from both control subjects (p = 0.0004) and those with inactive disease (p = 0.03). Peripheral blood lymphocytes contained no placental ferritin. It was present, however, in lamina propria lymphocytes of intestinal biopsy specimens from active coeliacs. Placental ferritin was also found in some of the better differentiated malignant cells in two patients with adult onset enteropathy associated lymphoma. Placental ferritin is known to have an immunosuppressive effect, and this may be one of the necessary steps in the development of malignancy associated with coeliac disease. Gluten free diet, by reversing this state, may have a role in the prevention of lymphoma.
胎盘铁蛋白是一种肿瘤相关抗原，存在于活动性霍奇金淋巴瘤和非霍奇金淋巴瘤患者的血清中，疾病缓解期血清值会下降。胎盘铁蛋白与全血铁蛋白值之间无相关性。由于乳糜泻与淋巴瘤之间存在密切关联，对19例活动性乳糜泻患儿和25例非活动性乳糜泻患儿进行了胎盘铁蛋白检测。32例患有其他肠道疾病的患儿作为对照。采用酶联免疫吸附测定法（ELISA），用单克隆抗体鉴定胎盘铁蛋白。对照血清中胎盘铁蛋白的平均（标准误）值为12.6（2.4），而活动性和非活动性乳糜泻患者血清中的值分别为117（22.8）和43.8（10.2）U/ml。活动性乳糜泻患者与对照受试者（p = 0.0004）和非活动性疾病患者（p = 0.03）均有显著差异。外周血淋巴细胞不含胎盘铁蛋白。然而，在活动性乳糜泻患者肠道活检标本的固有层淋巴细胞中存在胎盘铁蛋白。在两名成年发病的肠病相关淋巴瘤患者的一些分化较好的恶性细胞中也发现了胎盘铁蛋白。已知胎盘铁蛋白具有免疫抑制作用，这可能是乳糜泻相关恶性肿瘤发生发展的必要步骤之一。无麸质饮食通过逆转这种状态，可能在预防淋巴瘤中发挥作用。
