Caritis S N, Carson D, Greebon D, McCormick M, Edelstone D I, Mueller-Heubach E
Am J Obstet Gynecol. 1982 Jan 15;142(2):183-90. doi: 10.1016/s0002-9378(16)32334-1.
Ninety-two women in preterm labor were randomly assigned to either terbutaline or ethanol. In women with intact membranes, terbutaline was significantly more effective than ethanol in preventing progressive cervical dilation during the first 36 hours of treatment while betamethasone was given to the mother. Additionally, pregnancy was maintained significantly longer in women with intact membranes who were treated with terbutaline (15 +/- 4 days) rather than with ethanol (10 +/- 3 days). However, only 18% of women in each treatment group maintained their pregnancy beyond 36 weeks' gestation. In women with ruptured membranes and cervical dilation less than 4 cm, terbutaline was significantly better than ethanol in maintaining pregnancy for a minimum of 36 hours. Serious maternal side effects were not observed with terbutaline or ethanol, although a majority of women also received betamethasone. Neither drug caused serious adverse neonatal effects.
92名早产女性被随机分为两组，分别接受特布他林或乙醇治疗。对于胎膜完整的女性，在治疗的前36小时内给予母亲倍他米松的同时，特布他林在预防宫颈进行性扩张方面显著优于乙醇。此外，胎膜完整且接受特布他林治疗的女性（15±4天）比接受乙醇治疗的女性（10±3天）维持妊娠的时间显著更长。然而，每个治疗组中只有18%的女性妊娠维持超过36周。对于胎膜破裂且宫颈扩张小于4cm的女性，特布他林在维持妊娠至少36小时方面显著优于乙醇。使用特布他林或乙醇均未观察到严重的母亲副作用，尽管大多数女性也接受了倍他米松。两种药物均未引起严重的新生儿不良影响。
