Adamson I Y, Bowden D H
Am J Pathol. 1982 Jan;106(1):40-6.
Macrophagic production and particulate penetration into the lung were studied in mice depleted of monocytes by whole body irradiation. Subsequent intratracheal instillation of 4 mg carbon resulted in a much smaller adaptive increase in the number of alveolar macrophages, as compared with nonirradiated animals. The decreased macrophagic output was associated with increased passage of free carbon across the Type 1 alveolar epithelium in increased accumulation of carbon in interstitial macrophages and hilar lymph nodes of irradiated mice. The results suggest that interference with the adaptive outpouring of alveolar macrophages following a particulate load facilitates the interaction of particles with macrophages within the pulmonary interstitium, where fibrogenic factors released in response to toxic agents would have a maximum effect.
通过全身照射使小鼠单核细胞耗竭，研究了巨噬细胞的产生以及颗粒物质向肺内的渗透情况。与未受照射的动物相比，随后经气管内注入4毫克碳后，肺泡巨噬细胞数量的适应性增加要小得多。巨噬细胞产出的减少与游离碳穿过I型肺泡上皮的增加以及照射小鼠间质巨噬细胞和肺门淋巴结中碳积累的增加有关。结果表明，颗粒负荷后对肺泡巨噬细胞适应性流出的干扰促进了颗粒与肺间质内巨噬细胞的相互作用，在肺间质中，对有毒物质作出反应而释放的纤维生成因子会产生最大效应。
