抗生素结合在预防血管假体感染中的作用。
The role of antibiotic bonding in the prevention of vascular prosthetic infections.
作者信息
Greco R S, Harvey R A
出版信息
Ann Surg. 1982 Feb;195(2):168-71. doi: 10.1097/00000658-198202000-00008.
Abstract
Oxacillin, a negatively charged antibiotic, was bonded to polytetrafluoroethylene (PTFE) grafts using the cationic surfactant, benzalkonium chloride. Control PTFE grafts and bonded grafts prepared at room temperature and at 90 C were placed in the infrarenal aorta of dogs and challenged by local contamination with Staphylococcus aureus. Bonded grafts were superior to controls in negative cultures, patency, and survival. The possible role of antibiotic bonding in the prevention of vascular prosthetic infection is discussed.
摘要
苯唑西林是一种带负电荷的抗生素，通过阳离子表面活性剂苯扎氯铵与聚四氟乙烯（PTFE）移植物结合。将在室温及90℃下制备的对照PTFE移植物和结合移植物置于犬的肾下腹主动脉中，并通过金黄色葡萄球菌局部污染进行激发试验。在阴性培养、通畅率和存活率方面，结合移植物优于对照移植物。本文讨论了抗生素结合在预防血管假体感染中的可能作用。
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本文引用的文献
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Diffusion of antibiotics from a polytetrafluoroethylene-benzalkonium surface.抗生素从聚四氟乙烯-苯扎氯铵表面的扩散。
Am Surg. 1981 Dec;47(12):515-8.
2
The noncovalent bonding of antibiotics to a polytetrafluoroethylene-benzalkonium graft.抗生素与聚四氟乙烯-苯扎氯铵接枝物的非共价键合。
Ann Surg. 1981 Nov;194(5):642-7. doi: 10.1097/00000658-198111000-00015.
3
Antibiotic bonding to vascular prostheses.
J Thorac Cardiovasc Surg. 1981 Aug;82(2):272-7.
4
Prosthetic arterial graft material. Influence on neointimal healing and bacteremic infectibility.
Arch Surg. 1980 Nov;115(11):1379-83. doi: 10.1001/archsurg.1980.01380110111017.
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Antibiotic prophylaxis in vascular surgery.血管外科中的抗生素预防
Ann Surg. 1978 Sep;188(3):283-9. doi: 10.1097/00000658-197809000-00003.
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Studies of a graphite-benzalkonium-oxacillin surface.石墨-苯扎氯铵-苯唑西林表面的研究。
Am Surg. 1979 Dec;45(12):774-9.
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