抗生素结合在预防血管假体感染中的作用。
The role of antibiotic bonding in the prevention of vascular prosthetic infections.
作者信息
Greco R S, Harvey R A
出版信息
Ann Surg. 1982 Feb;195(2):168-71. doi: 10.1097/00000658-198202000-00008.
Oxacillin, a negatively charged antibiotic, was bonded to polytetrafluoroethylene (PTFE) grafts using the cationic surfactant, benzalkonium chloride. Control PTFE grafts and bonded grafts prepared at room temperature and at 90 C were placed in the infrarenal aorta of dogs and challenged by local contamination with Staphylococcus aureus. Bonded grafts were superior to controls in negative cultures, patency, and survival. The possible role of antibiotic bonding in the prevention of vascular prosthetic infection is discussed.
苯唑西林是一种带负电荷的抗生素，通过阳离子表面活性剂苯扎氯铵与聚四氟乙烯（PTFE）移植物结合。将在室温及90℃下制备的对照PTFE移植物和结合移植物置于犬的肾下腹主动脉中，并通过金黄色葡萄球菌局部污染进行激发试验。在阴性培养、通畅率和存活率方面，结合移植物优于对照移植物。本文讨论了抗生素结合在预防血管假体感染中的可能作用。
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