Horton J, Ogden M E, Williams S, Coln D
Ann Surg. 1982 Feb;195(2):172-6. doi: 10.1097/00000658-198202000-00009.
Overwhelming infection from encapsulated bacteria occurs after splenectomy. Decreases in IgM, tufsin, and serum opsonin are known to occur in animals and humans after splenectomy. A substantial immunologic advantage exists if some splenic tissue remains, but this may not offer sufficient protection from encapsulated bacteria if splenic arterial blood flow is reduced. This experiment was designed to examine the rate of pneumococcal clearance by the spleen and to determine the relationship between splenic blood flow and splenic tissue mass in bacterial clearance from the blood. Pneumococcal clearance, splenic blood flow, and residual splenic weight were measured in 171 rabbits with normal spleens, ligated splenic arteries, splenic autotransplants, hemisplenectomies, and splenectomies. Interruption of the splenic artery results in delayed pneumococcal clearance that is due to reduced blood flow and not to a decrease in splenic tissue mass. Splenic artery ligation to preserve an injured spleen cannot be assumed to give protection from sepsis.
脾切除术后会发生由包膜细菌引起的严重感染。已知脾切除术后动物和人类体内的IgM、tuftsin和血清调理素会减少。如果保留一些脾组织，则存在显著的免疫优势，但如果脾动脉血流减少，这可能无法提供足够的保护以抵御包膜细菌。本实验旨在研究脾脏清除肺炎球菌的速率，并确定脾血流与脾组织质量在血液细菌清除中的关系。对171只具有正常脾脏、脾动脉结扎、自体脾移植、半脾切除和脾切除的兔子测量了肺炎球菌清除率、脾血流和残余脾脏重量。脾动脉中断会导致肺炎球菌清除延迟，这是由于血流减少而非脾组织质量下降所致。不能认为结扎脾动脉以保留受损脾脏就能预防败血症。
