Cartwright J D
S Afr Med J. 1978 Jul 8;54(2):65-7.
Newborn infants given one of three BCG vaccines at birth reacted to Heaf tuberculin testing 6-12 weeks later with a visible and palpable ring of nodules. This correlated with the Heaf grade I reaction previously describes with BCG vaccination. Review of hospital and clinic records, although regrettably incomplete, revealed no case of tuberculous meningitis or miliary tuberculosis in a vaccinated child in our area since the campaign for vaccination of newborn babies began. Tuberculosis in vaccinated babies should be carefully investigated to determine age at vaccination, type of vaccine, degree of exposure to infection and socio-economic factors which may be important in producing this "vaccine failure". Vaccination will give 60-80% protection to the newborn for about 5 years.
出生时接种三种卡介苗之一的新生儿，在6至12周后接受希夫结核菌素检测时，出现了可见且可触及的结节环。这与先前描述的卡介苗接种后的希夫I级反应相关。对医院和诊所记录的回顾（遗憾的是并不完整）显示，自新生儿疫苗接种运动开始以来，我们地区接种疫苗的儿童中没有结核性脑膜炎或粟粒性结核病的病例。对接种疫苗的婴儿患结核病的情况应进行仔细调查，以确定接种疫苗的年龄、疫苗类型、感染接触程度以及可能对导致这种“疫苗失效”很重要的社会经济因素。疫苗接种将为新生儿提供约60%至80%的保护，持续约5年。
