Madden T D, Cullis P R
Biochim Biophys Acta. 1982 Jan 4;684(1):149-53. doi: 10.1016/0005-2736(82)90061-x.
The structural preferences of mixed lipid systems containing egg yolk or 18:1c/18:1c phosphatidylethanolamine and representative detergents (Triton X-100, deoxycholate, octylglucoside and lyso-phosphatidylcholine) have been examined. It is shown that all these detergents exhibit an ability to stabilize a bilayer organization for the phosphatidylethanolamine at detergent to phosphatidylethanolamine molar rations of 0.05 to 0.5, depending on the detergent and/or phosphatidylethanolamine species. These results are interpreted in terms of molecular shape, where the 'inverted cone' shape detergents combine in a complementary fashion with 'cone shaped' phosphatidylethanolamine to result in net bilayer structure.
研究了含有蛋黄或18:1c/18:1c磷脂酰乙醇胺以及代表性去污剂（Triton X-100、脱氧胆酸盐、辛基葡糖苷和溶血磷脂酰胆碱）的混合脂质体系的结构偏好。结果表明，所有这些去污剂在去污剂与磷脂酰乙醇胺的摩尔比为0.05至0.5时，都具有稳定磷脂酰乙醇胺双层结构的能力，这取决于去污剂和/或磷脂酰乙醇胺的种类。这些结果从分子形状的角度进行了解释，其中“倒锥形”去污剂与“锥形”磷脂酰乙醇胺以互补方式结合，从而形成净双层结构。
