Diedericks R, Coovadia H M
S Afr Med J. 1978 Jul 29;54(5):208-10.
The immunopathogenesis of the nephrotic syndrome which occurs in about 0,3% of Black children with post-streptococcal glomerulonephritis has not been clearly defined. Findings in 2 out of 582 Black children with post-streptococcal glomerulonephritis who developed nephrotic syndrome suggest that minimal activation in the blood of complement components, particularly C3, early in the nephritic process may determine progression to nephrosis. Differences reported by other workers between normocomplementaemic and hypocomplementaemic patients with post-streptococcal glomerulonephritis support this interpretation.
在患链球菌感染后肾小球肾炎的黑人儿童中，约0.3%会发生肾病综合征，其免疫发病机制尚未明确界定。在582例患链球菌感染后肾小球肾炎并发展为肾病综合征的黑人儿童中，有2例的研究结果表明，在肾炎过程早期，血液中补体成分（尤其是C3）的轻度激活可能决定了病情是否会进展为肾病。其他研究人员报告的链球菌感染后肾小球肾炎的正常补体血症患者和低补体血症患者之间的差异支持了这一解释。
