一种新的血红蛋白电泳变异体（奥吉），其中α链第34位的亮氨酸残基被精氨酸残基取代。
A new electrophoretic variant of hemoglobin (Ogi) in which a leucine residue is replaced by an arginine residue at position 34 of the alpha-chain.
作者信息
Sugihara J, Imamura T, Yamada H, Imoto T, Matsuo T, Sumida I, Yanase T
出版信息
Biochim Biophys Acta. 1982 Feb 4;701(1):45-8. doi: 10.1016/0167-4838(82)90310-7.
PMID:7055587
Abstract
Hemoglobin Ogi, in which an arginine is substituted for a leucine residue at position 34 of the alpha-chain, was detected in a Japanese family. Although slightly increased oxygen affinity is associated with this amino acid substitution in the alpha 1 beta 1 contact, it is without obvious deleterious effect on the hematological parameters of the individuals heterozygous for this variant.
摘要
在一个日本家庭中检测到了血红蛋白奥吉，其α链第34位的亮氨酸残基被精氨酸取代。尽管α1β1接触中的这种氨基酸取代与氧亲和力略有增加有关，但它对这种变体杂合子个体的血液学参数没有明显的有害影响。
相似文献
1
A new electrophoretic variant of hemoglobin (Ogi) in which a leucine residue is replaced by an arginine residue at position 34 of the alpha-chain.一种新的血红蛋白电泳变异体（奥吉），其中α链第34位的亮氨酸残基被精氨酸残基取代。
Biochim Biophys Acta. 1982 Feb 4;701(1):45-8. doi: 10.1016/0167-4838(82)90310-7.
2
Hemoglobin Athens-Georgia, or alpha 2 beta 2 40(C6)Arg replaced by Lys, a hemoglobin variant with an increased oxygen affinity.雅典-佐治亚血红蛋白，即α2β2 40（C6）位的精氨酸被赖氨酸取代，是一种氧亲和力增加的血红蛋白变异体。
Biochim Biophys Acta. 1976 Jul 19;439(1):70-6. doi: 10.1016/0005-2795(76)90162-8.
3
Hemoglobin Okaloosa (beta 48 (CD7) leucine leads to arginine). An unstable variant with low oxygen affinity.奥卡卢萨血红蛋白（β48（CD7）亮氨酸突变为精氨酸）。一种具有低氧亲和力的不稳定变体。
J Clin Invest. 1973 Nov;52(11):2858-64. doi: 10.1172/JCI107482.
4
Hemoglobin Suan-Dok (alpha 2 109 (G16) Leu replaced by Arg beta 2): an unstable variant associated with alpha-thalassemia.
Hemoglobin. 1979;3(2-3):161-74. doi: 10.3109/03630267908998911.
5
Hemoglobin Hotel-Dieu beta 99 Asp replaced by Gly (g1). A new abnormal hemoglobin with high oxygen affinity.血红蛋白迪厄酒店β99位天冬氨酸被甘氨酸取代（g1）。一种具有高氧亲和力的新型异常血红蛋白。
Hemoglobin. 1981;5(1):19-31. doi: 10.3109/03630268108996908.
6
Hemoglobin bologna (alpha 2 beta 2 61 (E5) lys replaced by met). An abnormal human hemoglobin with low oxygen affinity.
Biochim Biophys Acta. 1981 Apr 28;668(2):209-15. doi: 10.1016/0005-2795(81)90028-3.
7
Hb Godavari [alpha 95(G2)Pro-->Thr]: a neutral amino acid substitution in the alpha 1 beta 2 interface that modifies the electrophoretic mobility of hemoglobin.血红蛋白戈达瓦里[α95(G2)脯氨酸→苏氨酸]：α1β2界面处的中性氨基酸取代，改变了血红蛋白的电泳迁移率。
Hemoglobin. 1998 Jan;22(1):11-22. doi: 10.3109/03630269809071513.
8
Characterization of hemoglobin Burke [beta 107 (G9) Gly replaced by Arg].血红蛋白伯克的特征[β107（G9）位的甘氨酸被精氨酸取代]
Biochem Genet. 1976 Aug;14(7-8):577-85. doi: 10.1007/BF00485836.
9
Oxygen equilibrium of hemoglobin J Cape Town.血红蛋白J开普敦的氧平衡
J Clin Invest. 1971 Jul;50(7):1554-5. doi: 10.1172/JCI106642.
10
Hemoglobin Great Lakes (beta 68 [E12] leucine replaced by histidine): a new high-affinity hemoglobin.
Blood. 1981 Oct;58(4):813-7.
Zotero 插件